The Helmsley Charitable Trust is focused on finding a cure for Crohn’s disease. This is a long-term pursuit, so in parallel we are dedicated to improving patients’ lives today.
The creation of a Gut Cell Atlas, with Helmsley support, will offer tremendous potential to achieve both goals. It will enable better understanding of the disease and spur new, more personalized treatments on the path to prevention and a cure – not just for Crohn’s disease, but for improving gut health overall.
“The Gut Cell Atlas will offer unparalleled insights into what we know about ourselves and our gut, including the role of each cell in keeping us healthy – or causing disease. Mapping the cells of the gut is a critical step to realizing our goal of precise, personalized, and effective treatments for Crohn’s patients, while pursuing a cure.”
Anindita (Oni) Basu, University of Chicago
Jellert Gaublomme, Columbia University
Keith Wilson, Vanderbilt University Medical Center
Here is the latest news about the Gut Cell Atlas. We will post updates about research, meetings, and publications.
Today, The Leona M. and Harry B. Helmsley Charitable Trust announced $13 million in new grants to create a Gut Cell Atlas, cataloguing the many cell types in the small and large intestines. The initiative aims to understand distinct cell functions and interactions in human health and Crohn’s disease.
“Our bodies are made of tens of trillions of cells of many different types that work together to maintain function in the face of constant change, like a fine-tuned symphony; disease occurs when these cells no longer work together in harmony.”
“By building an atlas of cells in the colon of healthy individuals or individuals with Crohn’s disease, we should be able to identify key cell types involved in the disease, and understand the molecules driving their behavior, which could lead to new therapies.”
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